![]() ![]() The reversal of benzodiazepine effects may be associated with the onset of seizures in certain high-risk populations.In patients who are showing signs of serious cyclic antidepressant overdose.In patients who have been given a benzodiazepine for control of a potentially life-threatening condition (e.g., control of intracranial pressure or status epilepticus).In patients with a known hypersensitivity to flumazenil or benzodiazepines.There is limited information regarding Off-Label Non–Guideline-Supported Use of Flumazenil in pediatric patients. There is limited information regarding Off-Label Guideline-Supported Use of Flumazenil in pediatric patients. Off-Label Use and Dosage (Pediatric) Guideline-Supported Use Children 1 year or older, 0.01 mg/kg IV over 15 seconds if adequate sedation reversal does not occur after an additional 45 seconds, further injections of the same dosage may be repeated at 1-minute intervals, as needed up to 4 times.Patients below the age of 1 year have not been established.Flumazenil injection is indicated for the reversal of conscious sedation induced with benzodiazepines.Pediatric Indications and Dosage FDA-Labeled Indications and Dosage (Pediatric) There is limited information regarding Off-Label Non–Guideline-Supported Use of Flumazenil in adult patients. There is limited information regarding Off-Label Guideline-Supported Use of Flumazenil in adult patients. Off-Label Use and Dosage (Adult) Guideline-Supported Use Slower titration rates of 0.1 mg/min and lower total doses may help reduce the frequency of emergent confusion and agitation.3 mg to 5 mg administered as 0.5 mg/min or 0.2 mg/minute titration rate to slowly awaken the patient over 5 to 10 minutes.For repeat treatment, no more than 1 mg (at 0.2 mg/min doses) should be given at any one time and no more than 3 mg should be given in any one hour. Resedation may be treated by giving a repeat dose at no less than 20 minute intervals.Slow the rate of administration of flumazenil.Second dose: 0.2 mg IV may be given and repeated at 60-second intervals as needed (up to a maximum of 4 additional times) to a maximum total dose of 1 mg, if desired level of consciousness is not obtained after waiting 45 seconds.Common adverse reactions include diaphoresis, injection site pain, dizziness, headache, abnormal vision, blurred vision, agitation.Īdult Indications and Dosage FDA-Labeled Indications and Dosage (Adult) General Principles Overviewįlumazenil is a benzodiazepine receptor antagonist that is FDA approved for the treatment of reversal of conscious sedation induced with benzodiazepines. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. ![]() WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. Associate Editor(s)-in-Chief: Gloria Picoy Disclaimer ![]()
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